I have a great idea, why don’t we study the impact of administering a dosage of mind altering substances so vast in quantity that it might kill an elephant. I know why don’t we give this to an elephant called Tusko.
Oh shit – what a surprise it has killed the elephant.
If a human model had been used to determine the dose of LSD, the calculated dose for an elephant of Tusko’s size (3000 kg) would be about 9mg of LSD. The “jolly” doctor decided to inject Tusko with 297mg – more than 30 times the effective oral dose for a human of Tusko’s weight.